373-MetroSCREEN: Mapping Pan-Cancer Metabolic Subtypes

Paper Talk · Jan 7, 2026 · 17m

This research introduces MetroSCREEN, a computational framework designed to map the metabolic landscape of individual cells by integrating gene expression with regulatory mechanisms. By analyzing single-cell transcriptomic data, the tool calculates MetaModule scores to identify specific metabolic subtypes and uses causal inference to pinpoint the internal and external factors driving these states. The authors demonstrate how metabolic reprogramming—such as the shift between glycolysis and oxidative phosphorylation—correlates with the specialized functions of fibroblasts and macrophages within…