601-Stimulation mapping and whole-brain modeling

Paper Talk · Mar 7, 2026 · 21m

This research investigates how the human brain's hierarchical structure influences its response to electrical stimulation by combining invasive and non-invasive electrophysiology with advanced mathematical modeling. By analyzing data from 36 patients, the study identifies a spatial gradient of excitability, where high-order cognitive networks exhibit much stronger and more integrated responses than low-order sensory regions. Using "virtual dissections" in a computational model, the authors demonstrate that these heightened responses in high-order networks are causally dependent on recurrent…