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Monoclonal Gammopathy of Clinical Significance
Monoclonal gammopathy of clinical significance (MGCS) is an overarching classification for non-malignant disorders directly caused by monoclonal proteins produced during clonal plasma cell proliferative disorders. These conditions encompass organ-specific diseases affecting the renal, neurological, cutaneous, and ocular systems, as well as complex multi-system syndromes like POEMS and Schnitzler syndrome. Because diagnosis often requires establishing a precise causal link between the protein and organ damage, clinicians must carefully differentiate true MGCS from coincidental associations…
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