557-Decoupling T Cell Exhaustion from Protective Memory
This research explores how transcription factors (TFs) dictate the differentiation of CD8+ T cells into distinct functional or dysfunctional states during infection and cancer. Using the Taiji pipeline, scientists mapped the regulatory fingerprints of nine cellular states, specifically contrasting protective tissue-resident memory (TRM) cells with terminally exhausted (TEXterm) cells. The study identifies the proteasome pathway as a previously unrecognized hallmark of T cell exhaustion and uses in vivo CRISPR screens to pinpoint TFs that drive these specific identities. Functional experiments…
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