668-Spatial Stem-Like Evasion in Residual Liver Cancer
This research investigates how hepatocellular carcinoma (HCC) persists as minimal residual disease following treatment and eventually causes cancer recurrence. By utilizing spatial analysis and high-resolution imaging on human samples and mouse models, the authors identified a specific neighborhood of cells where immunosuppressive macrophages interact with stem-like tumor cells. These interactions are driven by the TGFβ pathway, which allows cancer cells to evade the immune system and leads to the exhaustion of protective CD8+ T cells. The study demonstrates that dual-targeting of the PD-L1…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.