138-Clonal Evolution in Ovarian Cancer Drug Resistance
This paper details a study that tracked clonal evolution and drug resistance in high-grade serous ovarian cancer (HGSOC) patients. Researchers developed a method called CloneSeq-SV, which combines single-cell whole-genome sequencing (scWGS) with targeted deep sequencing of structural variants (SVs) in cell-free DNA (cfDNA) to monitor co-existing tumor populations over time. The study of 18 patients revealed that drug resistance often arises from the selective expansion of pre-existing clones present at diagnosis, which frequently exhibit distinctive genomic features like oncogene…
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