Latest / The Peptide Research Podcast / Episode 57: NAD+ Injections: Why Are So Many People Getting Them?

Transcript

Episode 57: NAD+ Injections: Why Are So Many People Getting Them? · The Peptide Research Podcast

• 0:45
  SPEAKER_01: Hello everyone and welcome back to the peptideresearch.us podcast.
• 0:50
  SPEAKER_01: I'm Amy Andrews, and I'm here with our expert Todd Collins.
• 0:53
  SPEAKER_01: And today we're tackling a molecule that's basically the fuel gauge for every single cell in your body.
• 1:00
  SPEAKER_01: We're talking about NAD.
• 1:03
  SPEAKER_02: Thanks, Amy.
• 1:03
  SPEAKER_02: It's great to be back.
• 1:05
  SPEAKER_02: And NAD plus, or nicotinamide adenine dinucleotide, is truly one of the most essential molecules in human biology.
• 1:13
  SPEAKER_02: Without it, your cells basically stop talking to each other and your energy production grinds to a halt.
• 1:19
  SPEAKER_01: That sounds pretty high stakes.
• 1:21
  SPEAKER_01: And before we dive into how this molecule manages our cellular power plants, I want to remind everyone that you can find high standard research materials and deep dive articles over at peptideresearch.us.
• 1:35
  SPEAKER_02: And before we go further, we need to get our compliance disclaimer out of the way.
• 1:39
  SPEAKER_02: All peptides and compounds discussed in this podcast relate to research use only.
• 1:44
  SPEAKER_02: Any references to data from animals, cells, or human studies relate exclusively to scientific literature and not to products from NRG biolabs.
• 1:53
  SPEAKER_02: These compounds are not approved drugs or dietary supplements and are not for human consumption.
• 1:59
  SPEAKER_02: Nothing in this podcast is medical advice.
• 2:02
  SPEAKER_01: Okay, Todd, let's get into the nitty-gritty.
• 2:04
  SPEAKER_01: NAD Plus is a coenzyme, but I like to think of it as a biological delivery truck carrying electrons around.
• 2:12
  SPEAKER_01: Is that a fair way to picture it?
• 2:14
  SPEAKER_02: That's actually a perfect analogy.
• 2:16
  SPEAKER_02: It's the primary electron carrier in the electron transport chain, which is the process our mitochondria use to create ATP, the actual currency of energy in the body.
• 2:27
  SPEAKER_02: So if NAD plus is the delivery truck, ATP is the cash that pays for every movement, every heartbeat, and every thought you have.
• 2:36
  SPEAKER_00: But here's the kicker.
• 2:37
  SPEAKER_00: As we get older, the fleet of trucks starts to disappear, right?
• 2:41
  SPEAKER_02: Exactly.
• 2:42
  SPEAKER_02: And that's why researchers are so focused on this.
• 2:45
  SPEAKER_02: As we age, oxidative stress and DNA damage actually consume our NAD plus levels, while our body's ability to build new trucks, the biosynthesis, slows down.
• 2:56
  SPEAKER_02: By the time we're in middle age, we might have half the NAD plus we had in our 20s.
• 3:00
  SPEAKER_02: It's a massive metabolic bottleneck.
• 3:03
  SPEAKER_01: Half?
• 3:04
  SPEAKER_01: That's wild.
• 3:05
  SPEAKER_01: So when people talk about feeling drained or having brain fog as they age, could that literally be their cells running out of the cash they need to function?
• 3:14
  SPEAKER_02: That's exactly what the research suggests.
• 3:16
  SPEAKER_02: When mitochondria don't have enough NAD plus, they can't convert nutrients into energy efficiently.
• 3:22
  SPEAKER_02: Think of it like a power plant trying to run on old wet coal.
• 3:26
  SPEAKER_02: It's smoky, it's inefficient, and it causes a lot of pollution in the form of oxidative stress, which then damages the cell even more.
• 3:34
  SPEAKER_01: So it's a downward spiral.
• 3:36
  SPEAKER_01: Your NAD plus drops, which causes damage, which then uses up more NAD to try and fix that damage.
• 3:43
  SPEAKER_01: How does BPC157 or other compounds fit into this?
• 3:48
  SPEAKER_01: I've heard researchers often look at NAD plus alongside things like MOT-C or SS31.
• 3:54
  SPEAKER_02: That's a great catch.
• 3:56
  SPEAKER_02: Those are what we call mitochondrial targeted compounds.
• 3:59
  SPEAKER_02: Researchers are looking at how they work together.
• 4:02
  SPEAKER_02: While NAD Plus provides the fuel, something like MOT C acts more like a software update for your metabolism, and SS-31 acts like a shield for the mitochondrial membrane.
• 4:13
  SPEAKER_02: When you put them together in a research setting, you're looking at a complete overhaul of cellular energy.
• 4:19
  SPEAKER_01: I see.
• 4:19
  SPEAKER_01: So it's like upgrading the fuel, the engine, and the armor all at once.
• 4:24
  SPEAKER_01: It's no wonder people are flocking to wellness clinics for this.
• 4:27
  SPEAKER_01: But why are we hearing so much about injectables specifically versus just taking a vitamin pill?
• 4:33
  SPEAKER_02: That's the bioavailability hurdle.
• 4:36
  SPEAKER_02: Oral NAD has to survive the digestive tract, the liver, and then find its way into the bloodstream.
• 4:42
  SPEAKER_02: Whereas researchers prefer injectable protocols because they bypass the gut toll booth, delivering the compound directly where it can be utilized.
• 4:50
  SPEAKER_02: It's a much more consistent way to study the effects on cellular repair and DNA integrity.
• 4:56
  SPEAKER_01: Speaking of DNA, let's talk about the sertuans.
• 5:00
  SPEAKER_01: I've heard these called the longevity genes, and apparently they need NAD plus to work.
• 5:05
  SPEAKER_02: They do.
• 5:06
  SPEAKER_02: SETOINs are a family of proteins that act like janitors for your DNA.
• 5:10
  SPEAKER_02: They go around repairing broken strands and making sure your genes are expressed correctly.
• 5:15
  SPEAKER_02: But here's the catch: certuins are NAD dependent, meaning if there's no NAD plus in the cell, the janitors just sit in the break room and don't do any cleaning.
• 5:25
  SPEAKER_02: When researchers provide exogenous NAD plus, they often see those janitors get right back to work.
• 5:31
  unknown: Ha!
• 5:31
  SPEAKER_01: I love that.
• 5:33
  SPEAKER_01: We've got to keep the janitors working.
• 5:35
  SPEAKER_01: And this is why the transparency from our sponsor, NRG Biolabs, is so vital.
• 5:40
  SPEAKER_01: If you're a researcher trying to wake up those cellular janitors, you need to know your compound is pure.
• 5:47
  SPEAKER_01: NRG Biolabs supports the highest standards of transparency, which you can explore at peptidesearch.us.
• 5:54
  SPEAKER_02: Precisely.
• 5:55
  SPEAKER_02: Research is only as good as the materials, and when you're studying something as foundational as mitochondrial health, purity is everything.
• 6:03
  SPEAKER_01: Todd, I want to touch on the mental clarity aspect.
• 6:07
  SPEAKER_01: So many people report that NAD feels like turning the lights back on in their brain.
• 6:12
  SPEAKER_01: What's happening there?
• 6:13
  SPEAKER_02: The brain is a massive energy hog.
• 6:16
  SPEAKER_02: It uses about 20% of your body's total oxygen and calories, even though it's only 2% of your weight.
• 6:22
  SPEAKER_02: So when mitochondrial function improves, the neurons have the energy they need to fire more efficiently.
• 6:28
  SPEAKER_02: Researchers are seeing that this doesn't just help with focus, it may also support neuroprotection and recovery from mental stress.
• 6:35
  SPEAKER_01: It sounds like it's becoming a cornerstone of what people call regenerative wellness, not just fixing an injury, but optimizing the whole system from the inside out.
• 6:45
  SPEAKER_02: It really is.
• 6:46
  SPEAKER_02: Whether it's athletes looking for better recovery or people just wanting to maintain their quality of life as they get older.
• 6:52
  SPEAKER_02: The research is shifting away from treating a symptom towards supporting the system, and NAD Plus is the ultimate systemic supporter.
• 7:00
  SPEAKER_01: Okay, let's do a quick recap for our listeners who are ready to jump into the research.
• 7:05
  SPEAKER_02: Sure.
• 7:05
  SPEAKER_02: Remember that NAD Plus is a coenzyme found in every cell.
• 7:09
  SPEAKER_02: It's essential for creating ATP energy and fueling DNA repair.
• 7:14
  SPEAKER_02: It naturally declines with age, which can lead to fatigue and slower recovery, but research into injectable NAD is showing it can help bypass digestion to help refuel the mitochondria and activate those longevity-linked sertuan proteins.
• 7:29
  SPEAKER_01: It's amazing how one molecule can have such a massive ripple effect across the entire body.
• 7:35
  SPEAKER_01: Todd, any final expert thoughts before we head out?
• 7:39
  SPEAKER_02: Oh, and one last thing that's easy to overlook.
• 7:42
  SPEAKER_02: A lot of researchers are finding that NAD works best when it's part of a lifestyle ecosystem.
• 7:47
  SPEAKER_02: It's not just about the compound, it's about how it works alongside sleep, nutrition, and exercise to create a foundation for cellular health that lasts.
• 7:57
  SPEAKER_01: That's the perfect way to wrap it up.
• 7:59
  SPEAKER_01: It's about the whole picture.
• 8:01
  SPEAKER_01: If you want to see the science for yourself or read the latest blog posts on mitochondrial health, make sure to visit peptidesearch.us.
• 8:09
  SPEAKER_01: If you liked this podcast and want to stay up to date on all the latest peptide research, you can find links to our website, Facebook page, and even our Discord channel in the podcast description below.
• 8:20
  SPEAKER_01: You can even sign up for our newsletter and get notified every time a new episode rolls out.
• 8:25
  SPEAKER_01: Thanks for listening today.
• 8:26
  SPEAKER_01: We'll see you next time.