065-Neutrophils drive tumour necrosis and metastasis

Paper Talk · Sep 13, 2025 · 19m

This article challenges the traditional understanding of tumor necrosis as a passive process, instead demonstrating that neutrophils actively induce tumor necrosis and promote metastasis. The research identifies a specific population of "vascular-restricted" neutrophils (Ly6GHighLy6CLow) that form neutrophil extracellular traps (NETs), leading to vascular occlusion and localized hypoxia within tumors. Crucially, the study shows that cancer cells in these oxygen-deprived (perinecrotic) regions undergo epithelial-to-mesenchymal transition (EMT), a process linked to increased metastatic…