402-Logic of Localized Mitochondrial Translation
Researchers developed LOCL-TL, a novel optogenetic tool that uses blue light to control a site-specific biotin ligase, allowing for the precise monitoring of protein translation within specific cellular regions. By applying this method to human mitochondria, the study discovered that approximately 20% of nuclear-encoded mitochondrial genes are synthesized directly at the outer mitochondrial membrane. The findings reveal a dual-strategy system where long proteins are recruited during translation via a bipartite signal, while short proteins are targeted through an AKAP1-mediated process…
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