1037-COZI: Optimizing Cellular Neighbor Preference
This research article introduces and evaluates COZI, a novel computational method for quantitative tissue analysis in the field of spatial omics. By deconstructing existing neighbor preference (NEP) methods into three core stages—neighborhood definition, quantification, and scoring—the authors identify a gap in current analytical frameworks regarding bi-directional directionality and statistical sensitivity. The study utilizes simulated and biological datasets, including breast cancer and myocardial infarction samples, to demonstrate that COZI superiorly distinguishes subtle tissue…
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