1558-Stromal Cell Senescence and Haematopoietic Fitness
This research examines how clonal haematopoiesis (CH), a pre-malignant state where mutated blood stem cells expand, alters the bone marrow microenvironment. Using mouse models and human samples, scientists discovered that mutant cells trigger cellular senescence specifically in mesenchymal stromal cells (MSCs) through the release of inflammatory cytokines like TNF-α and IL-6. This transformation of the surrounding niche is not just a byproduct of the mutations; it actively enhances the survival and fitness of the mutant cells over healthy ones. The study identifies this cellular crosstalk as…
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