656-Cellular Architecture in the Spinal Cord
This research presents a comprehensive epigenetic and spatial atlas of the healthy adult human spinal cord, focusing on the thoracic and lumbar segments. By utilizing innovative techniques like STAB-seq and STARmap, the authors identify "masked enhancers"—regulatory elements that activate genes through histone modifications without changing physical chromatin accessibility. The study reveals that glial cell diversity and gene regulatory networks are significantly influenced by their anatomical position along the spinal cord's length. Furthermore, the findings demonstrate that cells organize…
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