1078-SSpMosaic: Integrating Single-Cell and Spatial Omics

Paper Talk · Jun 4, 2026 · 21m

This paper introduce SSpMosaic, a novel computational framework designed to unify single-cell and spatial omics data through the use of interpretable metaprograms. By extracting and aligning high-order gene programs, the tool facilitates the integration of diverse datasets across different batches, species, and molecular modalities like transcriptomics and proteomics. This methodology enhances cell-type annotation and allows for high-resolution spatial deconvolution, mapping cellular distributions from broad tissue areas down to subcellular scales. A key innovation of the framework is its…