1657-Cross-Species Single-Cell Atlas of the Striatum

Paper Talk · Oct 8, 2026 · 27m

This comprehensive single-cell atlas of the human and mouse striatum provides a detailed map of neuronal diversity and subregional specialization. By profiling over 400,000 nuclei, researchers identified rare neuronal subtypes, such as outlier MSNs and ventral-enriched islands, while uncovering significant transcriptional differences between species. The study highlights how specific cell types and the dorsolateral-ventromedial axis determine susceptibility to Huntington’s disease and addiction. Integrating genetic risk data and pharmacological studies, the authors reveal human-specific sites…