Latest / Skin Anarchy / E.303: Botox W/Out The Needles: Introducing NO-TOX ft. Dr Sharad P. Paul, MD

Transcript

E.303: Botox W/Out The Needles: Introducing NO-TOX ft. Dr Sharad P. Paul, MD · Skin Anarchy

• 0:12
  SPEAKER_02: Diablo 4 has arrived.
• 0:14
  SPEAKER_02: That's the forces of hell gather.
• 0:16
  SPEAKER_02: Only you can stand in their way.
• 0:18
  SPEAKER_02: Journey across the expanse of the open world of sanctuary.
• 0:21
  SPEAKER_02: Choose from five powerful classes and progressive figure plays down.
• 0:26
  SPEAKER_02: Adventure with your friends and up to four player co-op with cross play and cross progression platforms.
• 0:35
  SPEAKER_02: We did and here.
• 0:46
  SPEAKER_03: I have such a phenomenal guest today.
• 0:49
  SPEAKER_03: I am so excited because I I know that, you know, I'm going to learn a lot and I know you guys are going to learn a lot.
• 0:56
  SPEAKER_03: And he is truly a master of his craft.
• 0:59
  SPEAKER_03: So without further ado, I want to introduce you guys to Dr.
• 1:03
  SPEAKER_03: Sherrod Paul.
• 1:04
  SPEAKER_03: Welcome to the show, Dr.
• 1:05
  SPEAKER_03: Sherrod.
• 1:06
  SPEAKER_03: I'm so excited you're here.
• 1:07
  SPEAKER_00: Yeah, I'm excited.
• 1:08
  SPEAKER_00: Thank you so much for having me.
• 1:10
  SPEAKER_03: Oh, it's such an honor to host you, sir.
• 1:12
  SPEAKER_03: I'm I'm really, really excited to talk to you because just for everyone listening, the brand that Dr.
• 1:19
  SPEAKER_03: Sharad has created is um, you know, it's known as No Talks by Dr.
• 1:23
  SPEAKER_03: Sherrod.
• 1:24
  SPEAKER_03: And it's just a beautiful brand.
• 1:25
  SPEAKER_03: It's really, really innovative.
• 1:27
  SPEAKER_03: So I want to dive into that.
• 1:28
  SPEAKER_03: But first, I want to hear from you, Dr.
• 1:30
  SPEAKER_03: Sherrod, about your journey and just everything that led up to you, you know, innovating and creating this.
• 1:36
  SPEAKER_03: If you could get us started.
• 1:38
  SPEAKER_00: Yeah, so I've been in um skin practice for a long time.
• 1:43
  SPEAKER_00: So it's now 25, 26 years.
• 1:47
  SPEAKER_00: And I think uh my main realization from dealing with various skin conditions is you can't really have bad health and good skin.
• 1:58
  SPEAKER_00: So really that's really the philosophy um behind my work is that being as um non-invasive, non-toxic, as healthy as possible, including when you're creating um skincare.
• 2:13
  SPEAKER_00: And I guess the second part of my um research from a medical thing, which was groundbreaking, I suppose there are two different ones.
• 2:20
  SPEAKER_00: One from a surgical point of view is really looking at how collagen and elastin um interplay when we operate on patients.
• 2:29
  SPEAKER_00: And the other one is really um the skin of color and melanization of skin.
• 2:36
  SPEAKER_00: So Dana Tedek fundamentally on the myth of race and how we're all the same and how all skin colors evolve.
• 2:44
  SPEAKER_00: So these are some of my real interests in medicine, especially skin.
• 2:50
  SPEAKER_00: Yeah.
• 2:51
  SPEAKER_03: Right.
• 2:51
  SPEAKER_03: No, I I, you know, I think that's very interesting that you started off with that, with the, especially with the skin of color, because that's an area that I've always been very um intrigued about.
• 3:01
  SPEAKER_03: You know, I think about a year or so ago, this conversation really started up.
• 3:06
  SPEAKER_03: And I, you know, I want to come back to that, but I I really want to know about all of the, because you've done such great work, you know, and you have so many accolades and awards.
• 3:14
  SPEAKER_03: Um, you know, you are a skin cancer expert.
• 3:17
  SPEAKER_03: So I I want you to talk about that a little bit in terms of um how how has that evolved, you know, through your career?
• 3:24
  SPEAKER_03: Like how did you get involved with skin cancer um you know, work and I guess research?
• 3:30
  SPEAKER_00: How did that all come about?
• 3:32
  SPEAKER_00: Yeah, I think my original training actually um residency was to in um plastic surgery.
• 3:37
  SPEAKER_00: Um, but really um so I was born in England.
• 3:41
  SPEAKER_00: Um my parents moved to India and I now live in New Zealand.
• 3:47
  SPEAKER_00: So when I came down under New Zealand and Australia, we have the highest rate of skin cancer in the world, largely because fair-skinned um population from the British Isles, the majority of the population here, and we are closer to the South Pole, which has the highest um UV index, um, ultraviolet index.
• 4:08
  SPEAKER_00: So, therefore, we actually have uh very high incidence of skin cancer.
• 4:14
  SPEAKER_00: So, what I really found is um, you know, the dermatology, people who did pure dermatology residencies, they were good in diagnosis, but not so good in the cutting.
• 4:23
  SPEAKER_00: And the plastic surgical side, they were good at cutting, not so good at diagnosing.
• 4:29
  SPEAKER_00: So, in the end, I also trained in um bit of both.
• 4:33
  SPEAKER_00: So, in the end, I ended up a skin cancer specialist, and we have a separate like skin cancer college here, and I'm a professor at the universities here, and so on and so forth.
• 4:44
  SPEAKER_00: So, really, my work overlaps both, but um, and I guess it's largely evolved because of the clinical need here, just because we I have the largest series of skin cancer patients anywhere in the world, I suppose.
• 4:58
  SPEAKER_00: So, I guess so that gives me a lot of avenues for research.
• 5:02
  SPEAKER_03: Wow, that's amazing.
• 5:03
  SPEAKER_03: You know, I I find that to be so intriguing because there have been so many times on this podcast where I've had this uh conversation with strict clinicians, right?
• 5:13
  SPEAKER_03: And I and I always bring up the idea of, you know, well, you can't be just on one side of the fence.
• 5:19
  SPEAKER_03: You know, there has to be this balance between the research and the clinical side.
• 5:24
  SPEAKER_03: And you have to have that balance.
• 5:26
  SPEAKER_03: So when I talk to, you know, someone as esteemed as you, you know, it really kind of validates that idea that I've always had where, you know, you can't do medicine without kind of getting your feet into both sides of the equation, you know.
• 5:39
  SPEAKER_03: So I find that to be very intriguing.
• 5:42
  SPEAKER_00: I think more than anything, it helps um keep your um clinical game up as well.
• 5:48
  SPEAKER_00: Because if you're researching, then you're also keeping up with the trends, but you're also leading the way and you're innovating.
• 5:56
  SPEAKER_00: So you're actually um changing your practice.
• 6:00
  SPEAKER_00: So some of the stuff I'm doing now wasn't stuff I even knew before.
• 6:06
  SPEAKER_00: And even as you mentioned, creation of new skin products and things like that, they came out of the research lab, but a lot of the stuff which I probably didn't know like 15 years ago.
• 6:18
  SPEAKER_00: So, so yeah, so it just naturally was.
• 6:21
  SPEAKER_03: Yeah, yeah.
• 6:22
  SPEAKER_03: No, I I can definitely see that.
• 6:24
  SPEAKER_03: I mean, you know, I I actually want to really dive into the brand because you've created something so just, I mean, for lack of a better term, very cool.
• 6:33
  SPEAKER_03: You know, I when I look at it as a consumer, this is really cool stuff, you know.
• 6:37
  SPEAKER_03: And as being a science nerd, I'm really nerding out over it.
• 6:41
  SPEAKER_03: Basically, for everyone listening, um, Dr.
• 6:43
  SPEAKER_03: Stroud's line, you know, it's skinned by Dr.
• 6:46
  SPEAKER_03: Schrod, and he's created a product called No Talks.
• 6:48
  SPEAKER_03: So, Dr.
• 6:49
  SPEAKER_03: Schrod, I want you to go into No Talks and talk about that journey because I know that it's been over 10 years in the development stage, right?
• 6:56
  SPEAKER_03: And so I would love for you to share that with us.
• 7:00
  SPEAKER_00: Yeah, so it really began with my research into skin lines.
• 7:04
  SPEAKER_00: So a large part of my research is into wrinkling and how skin ages and skin lines that form, and I guess the health aspects of it.
• 7:16
  SPEAKER_00: So, so another way of looking, like I said, you can't have bad health and good skin.
• 7:20
  SPEAKER_00: And what I found was a lot of the um things which happen at a cellular level when it comes to injury, aging, um, inflammation, and you know, stress, like anxiety, things like that also impact your skin because of the same molecular pathways.
• 7:40
  SPEAKER_00: So, what's interesting is in other words, if you've got uh if you have cancer or if you've got a chronic injury which hasn't been treated, or if you've got you're under chronic emotional stress, your skin automatically ages, right?
• 7:55
  SPEAKER_00: So, in in studying these things, we looked at so what are um elements which can actually help reverse some of these signs, and because you know, fundamentally everybody wants to look younger and have good skin.
• 8:07
  SPEAKER_00: I mean, I've fundamentally when people come to your practice, everybody wants to have better skin, right?
• 8:12
  SPEAKER_00: Yeah, um so so I guess in researching that we were looking at various different things.
• 8:18
  SPEAKER_00: So there's a combination of ingredients.
• 8:20
  SPEAKER_00: So, for example, if you look at what ended up being the Notox sort of formulation, it's a concoction of stuff, but some of the stuff you'd recognize instantly, um, like for example, hyaluronic acid, everybody knows because it's a natural uh moisturizer in the body, both in joints and you know, um connective tissue and skin.
• 8:42
  SPEAKER_00: And then you would have nysinamide, which we know is good for skin.
• 8:47
  SPEAKER_00: We also know it reduces even pre-cancerous lesion.
• 8:51
  SPEAKER_00: So obviously it means it reduces photoaging, the damage from and and then we know the amino acids.
• 8:57
  SPEAKER_00: So if you look at collagen, and if you just break it down, what is collagen?
• 9:02
  SPEAKER_00: It's really um just a mixture of various amino acids which are sort of wound around in a spiral.
• 9:09
  SPEAKER_00: And so you generally have you know glycine, proline, hydroxyproline, and then if you look at elastin, it's got um, you know, glycine and desmasine, isodesmasine, proline.
• 9:22
  SPEAKER_00: So fundamentally, uh, some of the stuff.
• 9:24
  SPEAKER_00: So therefore, if you look at the composite nortox, you you've got um proline, you've got lysine because that actually helps wind these strands together.
• 9:34
  SPEAKER_00: You've got trace element copper because we know that you know copper helps produce more collagen.
• 9:40
  SPEAKER_00: So it's a um, you know, as an aside in foods, you'd find trace element copper like in shelf fishing, things like cashews and things like that.
• 9:51
  SPEAKER_00: So I guess with various things, we were experimenting with different strengths of these various things, and then we found certain um antioxidant um superfoods.
• 10:01
  SPEAKER_00: So we've got um plukinitia volibus, which is really saturated, you know, is often used as a superfood.
• 10:10
  SPEAKER_00: So for some reason, adding that potentiated it.
• 10:13
  SPEAKER_00: So it's a concoction of various stuff in the final formulation, and of course, it's got um vitamin C, which is you know really good antioxidant, but there were bits of tricks in the formulation.
• 10:26
  SPEAKER_00: So, for example, vitamin C, as you know, is ascorbic acid and it's acidic.
• 10:30
  SPEAKER_00: And if you have copper and the same thing, it gets chillated.
• 10:34
  SPEAKER_00: So, therefore, we had to make it you know a little more alkaline form, sodium um uh in slightly different forms so that it wouldn't chillate out the copper and all that kind of stuff.
• 10:45
  SPEAKER_00: So those are all just a little bit of fun in the lab.
• 10:48
  SPEAKER_00: But yeah, I guess eventually when we ran a trial, we could actually see that measurably, as people used it, like within three weeks, you could actually see a reduction in wrinkled depth, not just seeds, but we could actually measure it, and which progressively um keeps improving.
• 11:05
  SPEAKER_00: But but I guess, like I said, fundamentally it's got no um toxins, it's topical, so it doesn't have any needles.
• 11:13
  SPEAKER_00: And I guess in skin, as you know, I was just looking you up and I and you know, you've done lots of great stuff yourself, and you know, you've spent a lot of time in you know, um medicine and business and also uh you know researching these kinds of things.
• 11:29
  SPEAKER_00: And so you'd know, you know, more skin care is really sold on emotion and not science.
• 11:34
  SPEAKER_00: And we were trying to add more science to the equation.
• 11:39
  SPEAKER_03: Yeah, no, I I absolutely love the science, and I love that you dove right in with the amino acids and stuff.
• 11:44
  SPEAKER_03: So everyone listening, Dr.
• 11:45
  SPEAKER_03: Schrod mentioned a few of the very fundamental amino acids that are, you know, used in a lot of protein structures in our body, you know, such as you mentioned, uh lysine, you know, it's found a lot, you know, proline.
• 11:56
  SPEAKER_03: These are all, you know, biochemistry-related processes.
• 12:00
  SPEAKER_03: And I think that, you know, diving into this kind of science is really the missing link, you know, if you ask me, not only as a scientist, but as a consumer.
• 12:09
  SPEAKER_03: So I, you know, I really like the fact that you're going straight to the point.
• 12:14
  SPEAKER_03: And I want to actually highlight how the clinical trial went for you.
• 12:18
  SPEAKER_03: Because in this industry, what I've noticed is that when people say there's a clinical trial being conducted, it's never specified whether it's an in vitro trial or an in-vivo trial.
• 12:30
  SPEAKER_03: And that kind of information I think is very important to understand.
• 12:33
  SPEAKER_03: So I would love for you to tell us about um your clinical trial and how it was conducted on real people and and groups.
• 12:42
  SPEAKER_00: I guess that that's that you actually raised an excellent point because that could be really our big um point of difference because we could really see um results in the lab.
• 12:53
  SPEAKER_00: So, for example, if you simply put um, you know, um lysine and proline things in a lab and you put you know, cultured, or you just put cultured cells, or you have just dealing with collagen and elastin in a lab, you can actually see improvement.
• 13:11
  SPEAKER_00: But you know, one of the things I've often said in medicine is our bodies are biological human beings, each one of us has different metabolism, different skin types, um, different diets, um, you know, different emotional states.
• 13:25
  SPEAKER_00: All of these make a big difference to what happens at a cellular level.
• 13:30
  SPEAKER_00: And indeed, uh, that's just merely reflected in skin.
• 13:34
  SPEAKER_00: So um, one of the things we always say is what works in a petri dish often doesn't work in real people, right?
• 13:42
  SPEAKER_00: So, what we found is it was very easy to create those changes.
• 13:45
  SPEAKER_00: And you know, there are plenty of needle-free serums and things you'll see around, and virtually all of them have identical trials on petri dishes because that's easy to create.
• 13:52
  SPEAKER_00: I mean, we've created it many times in the lab, but to translate it into human beings, that's what took this much time.
• 14:00
  SPEAKER_00: Eventually, we got around to running the trial a couple of years ago.
• 14:04
  SPEAKER_00: Uh, unfortunately, COVID hit, so it was actually planned as a much larger trial.
• 14:09
  SPEAKER_00: And so I'm based in New Zealand, and of course, we went into a big lockdown.
• 14:13
  SPEAKER_00: So, of course, with restrictions, it cut the trial short and the numbers shorter.
• 14:18
  SPEAKER_00: But what we were really interested in is one of the things, as you know, in any trial is you want the control to be sound.
• 14:27
  SPEAKER_00: So the problem is in these kinds of trials um in skin, for example, you can't really do a control trial unless you're treating conditions between two people, because two people may age differently.
• 14:41
  SPEAKER_00: So, one of the ways we thought is we did a within patient control.
• 14:45
  SPEAKER_00: In other words, we targeted areas.
• 14:48
  SPEAKER_00: So we told people, okay, what are the areas of concern for you?
• 14:51
  SPEAKER_00: If somebody said cross feet and around the eyes, they would use it around the eyes, and then they wouldn't use it around their um lip lines, but we were measuring both, so we were we were measuring the changes between the two.
• 15:05
  SPEAKER_00: And some people would use it or two out of three areas.
• 15:08
  SPEAKER_00: But what was interesting is I mean, the the single thing which stood out for me was that statistically, every time where people used the serum, it actually reduced wrinkle depth.
• 15:22
  SPEAKER_00: But actually, where they weren't using the serum, it actually didn't have the same effect.
• 15:27
  SPEAKER_00: In fact, wrinkles were getting worse because we're in harsh conditions in the southern hemisphere, and a lot of some people were outdozing.
• 15:34
  SPEAKER_00: And so, really, it was quite fascinating.
• 15:37
  SPEAKER_00: So that really gave us one validation.
• 15:40
  SPEAKER_00: The other thing, of course, was the fact that we could actually measure the wrinkle um depth reducing.
• 15:46
  SPEAKER_00: And in fact, it's also feedback from people, of course.
• 15:49
  SPEAKER_00: You know, people kept coming back and saying their friends were saying, Hey, you know, you've had some needles put in or some work done because you're looking younger.
• 16:00
  SPEAKER_00: And it was quite interesting.
• 16:00
  SPEAKER_00: I was a joke about this because when New Zealand went into our second lockdown, I think um uh we sell um it out of my practice here and online.
• 16:10
  SPEAKER_00: And what happened was I think their prime minister announced that we would go and lockdown at midnight, and at about 11:50, I had like the biggest number of orders coming in.
• 16:23
  SPEAKER_00: And I'm like, how are we going to ever ship these?
• 16:26
  SPEAKER_00: Because we can't, but I was just thinking if people are going to lockdown and they were thinking of buying the product, uh, that must be good.
• 16:36
  SPEAKER_03: Or they're not wrinkling well in lockdown, Dr.
• 16:39
  SPEAKER_03: Sharad.
• 16:39
  SPEAKER_00: That's I think you know, it's partly also, I think now, I think it's partly because I think when we're locked down, everything becomes Zoom and conference calls and everything else.
• 16:48
  SPEAKER_00: But I suppose people want to look better on camera, maybe.
• 16:52
  SPEAKER_03: Absolutely.
• 16:53
  SPEAKER_03: No, I think that's a really great point.
• 16:54
  SPEAKER_03: And, you know, just going back to the point you made about the Petri dish thing, you know, um, I can definitely, definitely um understand what you're saying here because for everyone listening, by the way, you know, um Dr.
• 17:06
  SPEAKER_03: Shaud mentioned that, you know, you can grow cells in a petri dish, right?
• 17:10
  SPEAKER_03: And also one component that I never hear uh brands talk about, which is something you're really addressing here, is that when you put something in a petri dish, when you grow cells in a petri as the cell culturing aspect of it, you're putting medium in there that is ideal for optimal growth of those cells, which is not the case of the body.
• 17:29
  SPEAKER_03: Like in the body, you're gonna have this internal milieu, which is gonna have cytokines and inflammatory molecules um circulating, which you're not gonna see in the medium, right?
• 17:38
  SPEAKER_03: In the petri dish.
• 17:39
  SPEAKER_03: So these are kind of things that I have always wondered, you know, it's like, why are they, why are they not addressed?
• 17:45
  SPEAKER_03: Like these little things.
• 17:46
  SPEAKER_03: Because as a scientist, you know, you know, we when you design and study, you have to keep all of these things in mind.
• 17:52
  SPEAKER_03: So there's a lot of brands out there that are like, yeah, we ran clinical trials, you know, all this stuff, but it's like, yeah, you ran clinical trials, but the cells had the optimal environment to grow.
• 18:02
  SPEAKER_03: So, you know, it was, it's a totally different kind of scenario.
• 18:05
  SPEAKER_03: So I really like that you brought that up, you know, and mentioned that.
• 18:09
  SPEAKER_00: In fact, I actually think you're doing a better job of explaining the science than I am.
• 18:14
  SPEAKER_00: That was very, very good what you just said.
• 18:16
  SPEAKER_00: But but I think, you know, the key thing I would say is that's the same reason why people respond to different medications differently, exactly the same, right?
• 18:25
  SPEAKER_00: Because when it's originally started, till it goes into further trials at the earlier stage, everything looks promising, right?
• 18:32
  SPEAKER_00: At a cellular level.
• 18:33
  SPEAKER_00: So you would often hear things, this new drug has come out for whatever it is, be dementia, whatever, and they'll say it shows great promise in the lab.
• 18:39
  SPEAKER_00: And of course, then it doesn't show it on people.
• 18:42
  SPEAKER_00: It's the same kind of stuff till you really test on real people and many people, you know, of different um types and different ages and different skin.
• 18:52
  SPEAKER_00: Um, you know, really um now.
• 18:54
  SPEAKER_03: I love that.
• 18:55
  SPEAKER_03: Yeah, no, I I agree with you.
• 18:56
  SPEAKER_03: And I think, you know, for me, I I really want to dive into this idea of how the the product is really mimicking uh the effects of Botox.
• 19:06
  SPEAKER_03: I want you to speak to us about that because you know, what is it that Botox does so that our audience understands versus what's happening here with Notox?
• 19:17
  SPEAKER_00: Okay.
• 19:17
  SPEAKER_00: I think um firstly, um Notox actually the name came out of my research paper because as you know, when you write a research paper, uh you sometimes shorten the large term, and Notox was actually stands for non-toxin-based wrinkle reducing serum.
• 19:35
  SPEAKER_00: And of course, when you're publishing in a paper, it gets shortened to Notox.
• 19:39
  SPEAKER_00: And then we thought look, it looked like a fun name, so it stuck.
• 19:44
  SPEAKER_00: But the reality, the fundamental difference is, of course, see, Botox is a paralytic toxin, as you know, it's the um botulinum toxin.
• 19:52
  SPEAKER_00: Um, so Botox fundamentally just paralyzes your muscles.
• 19:57
  SPEAKER_00: So obviously, if you paralyze a muscle, then the skin doesn't move above it.
• 20:03
  SPEAKER_00: So um, therefore, the lines don't show, right?
• 20:06
  SPEAKER_00: So that's why Botox, particularly originally in medicine, um we used to use it to treat ticks and spasms and things like that, and it's still used for those purposes.
• 20:16
  SPEAKER_00: And then it caught on um as a cosmetic thing.
• 20:20
  SPEAKER_00: But the issue with Botox, of course, is it's an instance.
• 20:24
  SPEAKER_00: So, of course, nothing can work that quickly.
• 20:27
  SPEAKER_00: And so if you're look using it in areas, I mean, like speaking from a surgical point of view, if you use it in areas where muscles are immediately um, you know, under the skin.
• 20:37
  SPEAKER_00: So, for example, like your forehead, where the you know, muscles run down vertically from your scalp to your eyebrows, that allows you to elevate your eyebrows, raise them.
• 20:47
  SPEAKER_00: So, therefore, the muscle the lines run across.
• 20:51
  SPEAKER_00: So, what happens is if you injected Botox, of course, the lines vanish immediately because the muscle is paralyzed and your expression less.
• 20:59
  SPEAKER_00: So, of course, a product can't work as quickly, but what happens is over time it reduces the wrinkle depth.
• 21:06
  SPEAKER_00: So you still have wrinkles, but they won't be as noticeable.
• 21:10
  SPEAKER_00: So it won't be a complete paralysis which you get with Botox.
• 21:15
  SPEAKER_00: So, I guess the other thing which I would say then if you compare it with fillers, fillers use hyaluronic acid predominantly and a few other agents and are also injected.
• 21:26
  SPEAKER_00: And the idea is then it plumps up the skin from below, and therefore uh and the hyaluronic acid and therefore it reduces um the appearance of wrinkles.
• 21:36
  SPEAKER_00: The so I guess uh we probably um compare uh more to fillers than um borshocks, even though we have effects comparable to both.
• 21:48
  SPEAKER_00: But in fillers, again, it looks a bit uneven, always.
• 21:51
  SPEAKER_00: You can always tell when people have had a filler, right?
• 21:53
  SPEAKER_00: And and also with time it wears out and you need to do it.
• 21:56
  SPEAKER_00: So I guess it's the same, as long as you're using our product.
• 22:00
  SPEAKER_00: But progressively your skin keeps improving the wrinkle depth.
• 22:03
  SPEAKER_00: So what we found is in a trial at three weeks and then at six weeks and it continued 12 weeks, your wrinkle depth keeps reducing.
• 22:12
  SPEAKER_00: So more and more it gets um lesser and lesser.
• 22:15
  SPEAKER_00: And I guess if you stopped using it over several weeks again, uh or a few months, you would revert back slowly.
• 22:23
  SPEAKER_00: And I guess a similar effect with any of these things.
• 22:26
  SPEAKER_00: But the only big point of difference is there are no needles, uh, no toxins.
• 22:31
  SPEAKER_00: And literally every ingredient you can see in there is probably healthy for you anyway.
• 22:37
  SPEAKER_03: Yeah, no, I I really think that's so intriguing because you know, when you bring up the idea of Botox, like you said, we're talking on a muscle level, right?
• 22:45
  SPEAKER_03: And so uh, and then when you're thinking about something topical, we're talking about um the skin and the different layers.
• 22:52
  SPEAKER_03: And the so the idea of the molecular, like molecular level is very, very um, very different, right?
• 23:01
  SPEAKER_03: Because you're talking about neuromuscular junctions when you talk about a toxin being injected into your muscles.
• 23:07
  SPEAKER_03: But then here we have something that you're applying topically.
• 23:10
  SPEAKER_03: So we're not going down to the muscle level.
• 23:12
  SPEAKER_03: I would love for you to clarify that because when it comes to wrinkles, I think there's a lot of fog around what causes wrinkles, you know, and I and this is something I've always wondered because yeah, okay, you can go and opt for a needle, right?
• 23:27
  SPEAKER_03: And you can go and go to the muscle level, go deep.
• 23:30
  SPEAKER_03: But then what is that doing for the actual wrinkle?
• 23:33
  SPEAKER_03: Because the wrinkle is not in the muscle, the wrinkle is on the skin, right?
• 23:36
  SPEAKER_03: So where how is that, you know, I I'm just trying to find this like, I guess, comparison and maybe some clarification there between these two.
• 23:46
  SPEAKER_00: Yeah.
• 23:46
  SPEAKER_00: So actually, you've come to my um real um baby in advance in medicine, is really in skin lines.
• 23:53
  SPEAKER_00: So my research into skin lines, uh, there is a book, a surgical book I've written, which has been considered the first new way of looking at skin lines since like 1861.
• 24:05
  SPEAKER_00: So this is really my baby.
• 24:07
  SPEAKER_00: And so so fundamentally, skin is actually from a physics point of view, it's an elastic solid.
• 24:14
  SPEAKER_00: So it's all it actually behaves like a solid and it's elastic and it's draped over our bodies.
• 24:19
  SPEAKER_00: So, first thing to understand is skin is a barrier to the environment.
• 24:23
  SPEAKER_00: So, whatever's going on inside metabolically affects skin, and it also um helps exchange um you know between the environment and us.
• 24:33
  SPEAKER_00: So the second thing, first thing to understand is the skin, unlike what we may think, doesn't actually um give us shape, right?
• 24:41
  SPEAKER_00: So so therefore it's the fair share and the other things below it, which gives a body body shape.
• 24:45
  SPEAKER_00: So, for example, if you peeled off all your skin, you're not going to fall off like a big blob on the floor.
• 24:50
  SPEAKER_00: So, so what happens at the skin level is it really reflects what's going on both on the external environment or on the inside.
• 24:57
  SPEAKER_00: So, wrinkling is really um because of damage to the skin, and the damage, the most common um uh cause of wrinkling is of course photo damage, which is you know, um uh from sunlight.
• 25:09
  SPEAKER_00: And then, of course, we get damage from pollution, we get damage from things we don't realize, like even um altitude.
• 25:17
  SPEAKER_00: So, so so the various things, in fact, I will uh I was actually asked to do a documentary which we were filming halfway through, and then COVID hit, and we're going to resume it later this year where we're talking about some of these issues.
• 25:31
  SPEAKER_00: And so, what actually happens with skin is so the wrinkling is actually therefore a warning sign for you that something else is not um right.
• 25:39
  SPEAKER_00: So it could be spending too much time in the sun.
• 25:42
  SPEAKER_00: I guess if you ask me, then it's the S's, like you know, smokers will have um smoking, sunlight, lack of sleep, like the three S's, right?
• 25:52
  SPEAKER_00: So if you don't sleep enough, if you smoke, if you drink too much, if you spend too much time in the sun, all these will um uh, you know, make your wrinkles worse.
• 26:02
  SPEAKER_00: But also internally, um, your metabolism also affects it.
• 26:06
  SPEAKER_00: So, for example, sugar um causes glycation.
• 26:09
  SPEAKER_00: And so, you know, if you have a very high sugar diet, the damage would happen.
• 26:14
  SPEAKER_00: So all these things at a metabolic level affect wrinkles.
• 26:17
  SPEAKER_00: And what I found interesting, uh, I suppose this is a little bit technical, maybe for this podcast, but seeing that you're interested in science is when we analyze wrinkles, the um alignment of collagen was different at the side of a wrinkles and then to the base of the wrinkles.
• 26:34
  SPEAKER_00: Right.
• 26:34
  SPEAKER_00: So um so and that's and and and also uh it's just because the wrinkles end up being like a V structure.
• 26:41
  SPEAKER_00: And so you actually have so at a simplistic level, I suppose what's happening to a metabolism affects wrinkling.
• 26:49
  SPEAKER_00: So you're absolutely right.
• 26:50
  SPEAKER_00: So if you injected something underneath, um, then you're paralyzing the muscles, or the skin doesn't show its wrinkles, but actually they're still there, but it's just not moving effectively.
• 26:59
  SPEAKER_00: You paralyzed it.
• 27:00
  SPEAKER_00: So, in some ways, you're not going to get these warning signs that maybe you should address something else as well.
• 27:06
  SPEAKER_00: And because all your care fundamentally needs to be um holistic.
• 27:10
  SPEAKER_00: So I and one of the other things I do in research is we um look at um our genes, and one of my books is on health and the genetics of health, and one of the things, again, it comes out as we actually have specific genes which are related to skin function, elasticity.
• 27:29
  SPEAKER_00: So we can actually test somebody's genes and then say, look, for you, these kinds of foods are better, or you're more prone to getting um this kind of problem or a vitamin C like.
• 27:42
  SPEAKER_00: So therefore, you need more of this kind of product or that's kind of a product, things like that.
• 27:46
  SPEAKER_00: So that's where this is going.
• 27:48
  SPEAKER_00: But to going back to your first question, absolutely.
• 27:51
  SPEAKER_00: So the formulation is very key because it's very difficult to formulate hyaluronic acid in a format where it gets really well absorbed deep.
• 27:59
  SPEAKER_00: And that's one of the reasons where fillers came in, because you can inject them straight deep.
• 28:03
  SPEAKER_00: So that's where the delay was.
• 28:05
  SPEAKER_00: You know, even when we hit upon the correct combination at uh in a lab level where we could see changes in a petri dish, it took years to perfect the formulation till we could get enough skin absorption and penetration where we could um notice difference on actual um people.
• 28:23
  SPEAKER_03: That's really, really, really interesting.
• 28:25
  SPEAKER_03: I I just I love that you address it.
• 28:27
  SPEAKER_03: Thank you for addressing that because that is something I really wanted to clarify for everyone listen, you know, just listening is this idea of, you know, it's like thinking about what, you know, when I think of Botox, I think of like, you know, you're straightening out some bed sheets, right?
• 28:43
  SPEAKER_03: But you're not, it's it's not going to fix the problem of like, they're still gonna get wrinkled, you know, they're still there.
• 28:49
  SPEAKER_03: So this is a very bad analogy, I know.
• 28:51
  SPEAKER_03: But like, you know, that's that's how I imagine it.
• 28:53
  SPEAKER_03: And I think um when people discuss that, you know, I have wrinkles, now I need to get Botox, that's something I never understood was that, you know, well, why are you treating something on this like almost higher, I guess, uh level where, you know, it's almost like a macro level compared to, for example, what you what you just told us, which is the collagen, um, you know, just the pattern of collagen as you know, what's seen in the wrinkle itself.
• 29:17
  SPEAKER_03: So it's really, really interesting to me um the way you explain that.
• 29:20
  SPEAKER_03: Now, one thing I I really want to dive into is that you've created this brand that's amazing, but you've also covered so many things the beauty industry loves to talk about, like, you know, vegan products, it's natural, it's toxin-free, cruelty-free.
• 29:35
  SPEAKER_03: I mean, how did all of that come together?
• 29:37
  SPEAKER_03: Um, how what was the journey like when you were just trying to create this in that way, in that format?
• 29:43
  SPEAKER_00: I think um, to be honest, I was just trying to create as so I always joke saying the in all the research that I do, really, the only as an animal lover, the only animal testing is on me.
• 29:56
  SPEAKER_00: So I always like try to try out all the stuff um I'm developing.
• 30:01
  SPEAKER_00: And one of the things when we set out to do this, we didn't specifically set out saying this has to be vegan, but like I said, the fundamental underpinning philosophy is that you want good health and good skin.
• 30:15
  SPEAKER_00: So therefore, we do know that if you have less animal products on your skin, if you have less of these things, it's better.
• 30:24
  SPEAKER_00: So, so let me give you another example.
• 30:26
  SPEAKER_00: So, yeah, speaking of the beauty industry, another fat, of course, is you know, collagen, if you ingested it.
• 30:32
  SPEAKER_00: Oh, right.
• 30:33
  SPEAKER_00: So, so let me just explain this because this I was actually interviewed by the Times of London about collagen supplements.
• 30:40
  SPEAKER_00: And one of the interesting things which we find in the lab is if you ate collagen, it just gets digested like meat, right?
• 30:46
  SPEAKER_00: But what actually happens is, like we said earlier, you have glycine, proline, hydroxyproline.
• 30:51
  SPEAKER_00: But what's interesting is the body actually has no idea that you are taking it with the intention of trying to fix your skin, right?
• 31:01
  SPEAKER_00: So so if any of these gets absorbed, these amino acids will be directed by the body where you need the repair, and that's typically maybe your joints or something else.
• 31:10
  SPEAKER_00: So if there's any benefit, it could be in your joints or somewhere else, but it's not going to trickle up to your skin because the cells, just like genes, don't actually care about you, they're just doing their job.
• 31:21
  SPEAKER_00: So one of the things I like saying is genes are your blueprint, but they're not your destiny, right?
• 31:28
  SPEAKER_01: Right.
• 31:28
  SPEAKER_00: So if you look at product um things like elastin, they're actually single gene expressed um things, like they're all expressed by single genes.
• 31:39
  SPEAKER_00: And and one of the things is so, for example, if you ate bad foods, your genes would start expressing bad proteins, which end up being bad for you.
• 31:47
  SPEAKER_00: So your genes don't think like, don't think, look, I've got to look after Ecta because I'm in her body, so I'm not going to harm her.
• 31:55
  SPEAKER_00: No, they don't care her stuff.
• 31:56
  SPEAKER_00: So they're going to you know mess you up if you eat stuff which expresses the bad proteins.
• 32:02
  SPEAKER_00: So the same sort of thing with collagen is when you ingest it, body just directs it where you need products.
• 32:09
  SPEAKER_00: It doesn't actually care.
• 32:10
  SPEAKER_00: The envelope outside is your skin.
• 32:12
  SPEAKER_00: It doesn't actually think like that.
• 32:14
  SPEAKER_00: So there's a lot of myths in the beauty industry.
• 32:16
  SPEAKER_00: So that's one of the reasons why you know creating this took time because you have to try and see what's actually going to work at a level, what's going to penetrate deep enough, what's going to not be harmful for the person.
• 32:26
  SPEAKER_00: Because if you actually then ended up using something which was potentially more toxic, we do know eventually when it gets penetrated through, it's going to cause harmful effects, it's going to come back and bite you at your skin level anyway.
• 32:41
  SPEAKER_00: So I think it was really, like I said, the fundamental philosophy often felt is that you can't have a really, really bad lifestyle and end up with good skin.
• 32:51
  SPEAKER_00: Right.
• 32:52
  SPEAKER_00: So with it comes creating a product which mimics these good things in your lifestyle.
• 32:56
  SPEAKER_00: So obviously, you have, like I told earlier nice and which we know reduces effects of sun damage, vitamin C, we know helps wound healing.
• 33:05
  SPEAKER_00: So the various things in it which help different parts of um our health in general and also skin health.
• 33:14
  SPEAKER_03: Right.
• 33:15
  SPEAKER_03: No, that it makes a lot of sense, you know, and I'm so glad that you said what you said about ingesting collagen because I literally said this like I I forget which episode it was, but I I was just, I think it was uh another physician I was interviewing, and we were talking about this, and I was like, I don't know why people don't understand that, you know, it's like you know those vitamin B shots that everyone loves to take.
• 33:37
  SPEAKER_03: I'm like, you're just peeing that out, you know.
• 33:40
  SPEAKER_00: Yeah, yes, exactly.
• 33:41
  SPEAKER_00: Uh at least to joke about it, it creates expensive urine.
• 33:44
  SPEAKER_00: One of the things with collagen supplements, other risk in that is of course, most of the supplements are made out of ground hooves of cattle and things like that.
• 33:54
  SPEAKER_00: So you actually, the other concern I have is you know, long-term slow viruses and those kind of diseases you'd get because of the fact that they're all like they grind up hooves of cattle when they make up all these collagen powders, right?
• 34:07
  SPEAKER_03: Yeah, yeah.
• 34:10
  SPEAKER_03: I completely agree with you.
• 34:11
  SPEAKER_03: And I I think that you know, it's very interesting that we are coming to this juncture in this industry where we're trying to, you know, get the consumers on board with this idea that, you know, your body, like you said, is going to do what it needs to do.
• 34:25
  SPEAKER_03: So, you know, yeah, like you said, if I have wrinkles, my body it's like the fight or flight response, right?
• 34:31
  SPEAKER_03: In a way, because it's like your body is going to take care of what's most important.
• 34:36
  SPEAKER_03: You know, if you need vitamins or you need collagen somewhere else, like you have arthritis, you have something going on, it's gonna go there first.
• 34:43
  SPEAKER_03: It's not gonna go to your skin, like you said.
• 34:45
  SPEAKER_03: You know, it's it's all about like, you know, I I like to tell people like it's a machine, you know, your body's a machine.
• 34:51
  SPEAKER_03: So if you have a car engine and that engine is messed up, do you really think it's not, you know, which one uh do you think is gonna get fixed first?
• 34:59
  SPEAKER_03: The engine or like flat tires, right?
• 35:01
  SPEAKER_03: So it's like that.
• 35:02
  SPEAKER_00: Like you're but but absolutely, yeah, you're you're very right.
• 35:05
  SPEAKER_00: But actually, a one point um um which is key here is also that the peak of it, evolution is all about propagation of species.
• 35:15
  SPEAKER_00: So if you think about humanity evolved out of Africa, say 200,000 years ago and migrated out of Africa 100,000 years ago.
• 35:24
  SPEAKER_00: So really, we've been only around a very short span of time when the life on Earth has been around for two and a half billion years, right?
• 35:34
  SPEAKER_00: So, what happens is every creature shares skin with us.
• 35:39
  SPEAKER_00: So, so the beauty is it's our only universal organ, and all creatures have very similar receptors and skin.
• 35:46
  SPEAKER_00: So, the key thing in this is evolution cares about the species being propagated.
• 35:51
  SPEAKER_00: So, evolution cares about your reproductive peak, and that's one of the reasons why the genes and all these cells don't care about beauty um uh or cancers and things like that, is when you start losing your beauty or you start developing cancers, typically you're past your reproductive peak, right?
• 36:11
  SPEAKER_00: So, so that's one of the reasons why the genes and stuff, okay, you're starting to get wrinkles.
• 36:15
  SPEAKER_00: It's like, okay, you're already in your 40s, you're past your peak.
• 36:18
  SPEAKER_00: So they don't really care about it because there's no advantage at the biological level to reduce your wrinkles, right?
• 36:26
  SPEAKER_00: So that's why we have to help.
• 36:28
  SPEAKER_03: No, that makes total sense.
• 36:29
  SPEAKER_03: Yes, absolutely.
• 36:30
  SPEAKER_03: And you know, one one thing I really want to uh actually address here since you brought up the biological clock is this um that this product, both of your products are safe for pregnant women.
• 36:41
  SPEAKER_03: And I think that's so, so huge here.
• 36:44
  SPEAKER_03: So I would love for you to tell us about that and why um, you know, why that's such a big deal.
• 36:48
  SPEAKER_03: Because, you know, obviously there's a lot of women, regardless of whether they're pregnant or not, you know, they can I I've seen it in my own practice that they just ignore, you know, like for certain aesthetic procedures.
• 37:00
  SPEAKER_03: And it's it confuses me because I'm like, you need to be more careful.
• 37:04
  SPEAKER_03: I would love for you to talk about that, the pregnancy component.
• 37:08
  SPEAKER_00: Yeah, I think um so again, when I was developing this in the lab, we're really looking to create healthy skin and healthy body.
• 37:16
  SPEAKER_00: So as I said earlier, every ingredient, barring a few, um, it's the the key was the more secretive was the formulation, putting them together.
• 37:27
  SPEAKER_00: But if you went through the list, it's you know, there's seaweed, there's planktons, there's um, you know, copper, nestry amino acids, hyaluronic acid, niacinamide, so vitamin C.
• 37:38
  SPEAKER_00: Um, so if you looked at all these things, um, and then you find out that all these things are good for you even when they're ingested, so you can literally eat them.
• 37:47
  SPEAKER_00: So effectively, that's one of the reasons why it's safe in pregnancy is because we actually haven't got anything there which is toxic.
• 37:55
  SPEAKER_00: Um, but on the other hand, and and that should be, in my view, that should be the case with everything.
• 38:02
  SPEAKER_00: Um but of course, it often isn't.
• 38:04
  SPEAKER_00: But certainly, you know, at a when you're injecting something, obviously there's much more systemic changes happening because you're also creating an injury um to the um tissues underneath.
• 38:17
  SPEAKER_00: And of course, then the body has to respond, and then the body sensing a foreign body inside, which is not usually there.
• 38:23
  SPEAKER_00: Or if you're injecting a toxin, it has to respond.
• 38:25
  SPEAKER_00: So all these other things which we don't have as well.
• 38:27
  SPEAKER_00: So, yeah, so it's absolutely safe, you know, pregnancy, breastfeeding, whenever.
• 38:31
  SPEAKER_03: Yeah, no, I I think that's such a it's it's such an intriguing point because I think there's a lot of conversation about, you know, for example, you know, the perfect example is retinol.
• 38:41
  SPEAKER_03: And we always have this conversation in this industry, also in the science community about retinol use during pregnancy.
• 38:48
  SPEAKER_03: But then, you know, retinol, if you think about it again, right, is used for wrinkles.
• 38:52
  SPEAKER_03: So this is a really, really great option, you know, for people who maybe, you know, if you are pregnant or if you just don't even like to use retinol, you know, what you can this is a totally different approach to trying to combat the same issue.
• 39:06
  SPEAKER_03: So I would I actually want to get your um opinion about that in terms of the retinol and the use of like just kind of, I guess, outdated therapies and dermatology, because it's something I'm very passionate about too, right?
• 39:19
  SPEAKER_03: Because I think that a lot of the drugs that have been approved and, you know, whatnot, they're still they're they're old school drugs, you know.
• 39:26
  SPEAKER_03: It's like it's like, for example, I was talking to someone about um hydro uh hydroxychrinone, you know, and um they were talking about how, you know, it's uh it's made from a tree bark.
• 39:36
  SPEAKER_03: I was telling them, and it dates to 1600s, and we're still using that in medic medicine.
• 39:43
  SPEAKER_03: So when these kind of new innovations come out, I always wonder why, you know, like what is it going to take to really pick this up and go with this as the new standard, you know, of treating patients.
• 39:54
  SPEAKER_03: So I'd love to just get your thoughts on that.
• 39:57
  SPEAKER_00: I think um the two parts.
• 39:59
  SPEAKER_00: I think one of the things with um retinols are that I guess um there are the cosmetic retinols which are weaker, as you know, and then you have the medical grade ones, um, which are you know um 10 times stronger or more.
• 40:13
  SPEAKER_00: And in fact, it's an interesting thing you brought it up because in the lab we could actually, because in the Petri dish you can experiment with it, we actually compared um the notoxin um product ingredients against the medical grade retinol, not the cosmetic grade one, and we can actually see our effect on wrinkling um was actually comparable, if not better.
• 40:36
  SPEAKER_00: So actually, I've got a WHO, I mean, one of the WHO registered trials happening later this year, hopefully.
• 40:44
  SPEAKER_00: Um, and they we're actually going on one arm, we'll use our um Notox, and on the other arm, we're actually using a prescription grade written all for people who are using it.
• 40:55
  SPEAKER_00: But speaking about it, you're totally right.
• 40:58
  SPEAKER_00: Like, um, I mean, not everything which is ancient is useless because as you know, things like aspirin and all those things came out of natural low back.
• 41:07
  SPEAKER_00: But on the other hand, um, some of the medic the approaches to medicines were a lot more toxic, especially when you look at acne.
• 41:16
  SPEAKER_00: Like, like, for example, um, acne before, like if you looked at 30, 40 years ago, dermatologists even use radiation treatment for acne.
• 41:26
  SPEAKER_00: And just if you think about it, it makes me shudder, think of the harm.
• 41:30
  SPEAKER_00: So um, in fact, you brought up um hydroquinone.
• 41:35
  SPEAKER_00: Um, and what's interesting is um we can't actually use that topically down under here, which is banned because it increases the risk of hydroxychlonone and stuff, all the topicals, which uh is used for whitening and uh pigment reduction in the US, right?
• 41:50
  SPEAKER_00: You can get um topically available in the US, but you can't get them in Australia, New Zealand because they're banned here, because they increase the risk of skin cancer.
• 42:00
  SPEAKER_00: And like I said, we have the highest rate of skin cancer, but then but in the US, absolutely at demotrogic practices I see 2%, 4%, 8%.
• 42:09
  SPEAKER_00: Um, you can go to treat pigmentation.
• 42:12
  SPEAKER_00: And yes, you know, so so that is quite dangerous because on one hand, you're actually putting uh a little more toxic ingredients which are known to have other side effects and indeed cause harm to your skin, but you're doing it just with the immediate um effect of you're trying to see some faster acting results.
• 42:32
  SPEAKER_00: So you're not actually thinking about what else is going on at the cellular level.
• 42:36
  SPEAKER_00: So actually, that's a very, very interesting product you raised because we actually can't get it here.
• 42:41
  SPEAKER_00: But every time I travel to the US to deliver lectures or something, I see how widely it's used.
• 42:46
  SPEAKER_03: Yeah, it's very widely used.
• 42:48
  SPEAKER_03: And it's like, you know, there's so many of our listeners that reach out and they say, you know, I want to stop using my hydrokinole.
• 42:54
  SPEAKER_03: And I'm like, you have been using that first of all, you know, like I don't know why that, you know, dermatologists jump to these therapies, you know, even with something like, for example, you know, off topic, you brought up acne, but um, accutane, you know, accutane to me is like such a rudimentary, you know, medication at this point.
• 43:12
  SPEAKER_03: Like we don't need to be completely eradicating the human immune system and body and and just you know, just to treat acne.
• 43:20
  SPEAKER_03: You know, that's it does never make sense to me how radical our approach is when it comes to like just pharmaceutical therapies for, you know, um skin conditions.
• 43:29
  SPEAKER_03: And that's really, you know, even more interesting to me what you've created here, because this is this is a huge, I think, leap, you know, for in that field.
• 43:39
  SPEAKER_03: Because, you know, one of the biggest things that comes up also for me is dosing.
• 43:43
  SPEAKER_03: Dosing is something no one talks about.
• 43:45
  SPEAKER_03: You know, you hear about people saying, well, I got this many units of Botoxin.
• 43:49
  SPEAKER_03: Okay, but there's a limit right there.
• 43:51
  SPEAKER_03: So I want you to talk to us about that and how this product is actually, you know, it's why it's safer because of that reason, the dosing reason.
• 44:00
  SPEAKER_00: Yeah, I think like I said, it really doesn't have anything which is toxin in it, which is going to accumulate in the skin.
• 44:06
  SPEAKER_00: And because majority of the stuff are really um things which are broken down by the body and cells naturally anyway.
• 44:15
  SPEAKER_00: So if you look at like we said, you know, um proline and lysine and uh just the trace element, carbon isinamide, these are all things which are naturally found in uh many of the foods um we eat as well.
• 44:29
  SPEAKER_00: Um right.
• 44:30
  SPEAKER_00: And and so what it actually happens is it literally just gets digested by the skin.
• 44:35
  SPEAKER_00: And and because you're not injecting it, you're just giving it such a small amount, literally getting absorbed, which is literally immeasurable in your um serum.
• 44:45
  SPEAKER_00: Um, so what you actually find is um there is actually no risk in using it as opposed to absolutely um, you know, with you mentioned botoxima, I saw because I don't um do those treatments.
• 45:00
  SPEAKER_00: I'm not the expert on the levels of dosing, but what I can say is from seeing people come to me with the side effects, you know, of course, other than you know, little getting paralysis or being injected into wrong places and things, there are also, you know, microabscuses, there's an increase of um sort of um pseudo-tuberculosis kind of infections.
• 45:20
  SPEAKER_00: So the various other things can happen because of the fact that you're injecting a toxin into your system.
• 45:26
  SPEAKER_00: So I guess going back one step, like I said, this everything I would say it starts from my fundamental philosophy is if you don't address the underlying health, your own health, you can't um effectively address your skin because it's really just an envelope which drapes you and it's just going to reflect everything which is going on inside and outside.
• 45:48
  SPEAKER_00: So, so even when you are using the product, I would say, look, nothing is a miracle thing.
• 45:54
  SPEAKER_00: So you can, if you're going to be continuing to smoke a lot and continuing to not use sunscreen, spend a lot of time out in the sun, those kind of stuff, then you're still going to um get wrinkles.
• 46:07
  SPEAKER_00: You'll still notice some improvement, but it's not going to be as much as if you had a healthy lifestyle.
• 46:12
  SPEAKER_00: But actually, going one step back, and you were talking about is dosing and absorption.
• 46:17
  SPEAKER_00: One of my other areas research here, because it's in skin cancer, is in absorption of sunscreens, and that's why the sunscreens we make here are purely mineral, because they're just on the surface.
• 46:27
  SPEAKER_00: What people don't realize is when you use the chemical sunscreens, like you know, octane oxides and things like that, studies done which show four to five days after that it's still found in your urine and breast milk and this and that.
• 46:38
  SPEAKER_00: So people actually don't understand the dangers of more chemicals in sunscreens as well.
• 46:43
  SPEAKER_00: So it's really my philosophy generally is just do no harm, try and create good health, both from lifestyle as well as topicals.
• 46:55
  SPEAKER_03: I love that.
• 46:56
  SPEAKER_03: I think that's such a great point.
• 46:57
  SPEAKER_03: And especially in the world that we're living in, where now everyone is kind of, I think, you know, as clinicians and as researchers, we're trying to shift more towards this preventative approach to medicine, which I really, really am glad, you know, to see.
• 47:10
  SPEAKER_03: And I think, you know, this is something that's very important, especially for skin health, is this preventative idea, you know, and I would love for you to discuss that um, you know, with our listeners because I I think when it comes to skin care, there's a lot of people, you know, I feel like there's two groups of people.
• 47:27
  SPEAKER_03: There's people who just want to maintain their skin and they want it to stay, you know, as healthy as possible for a long time.
• 47:34
  SPEAKER_03: And then there are people who want a quick fix.
• 47:36
  SPEAKER_03: And I think that um the idea of prevention is not discussed enough.
• 47:41
  SPEAKER_03: So I would love for you to comment on that and and talk about the importance of um approaching it in from this preventative perspective.
• 47:49
  SPEAKER_00: That's right.
• 47:50
  SPEAKER_00: So uh effectively, because like I said, non-toxic ingredients are good for you and you can use it both as prevention and as treatment.
• 47:57
  SPEAKER_00: But if you're using it um before like um you have any wrinkles, obviously um your wrinkle depth reduces as they develop so they don't become as evident.
• 48:09
  SPEAKER_00: And if you're using it once you've got wrinkles, it will reduce the wrinkle depth.
• 48:13
  SPEAKER_00: But but I guess at one step back, um I've written in some of my books that so when I um did medicine, I also did medical law and philosophy and things.
• 48:26
  SPEAKER_00: So I'm full of useless information.
• 48:28
  SPEAKER_00: And one of the things I said is what struck me was medicine, like law was a guild.
• 48:32
  SPEAKER_00: And I've often said, um, see, law is not justice, just like medicine is in health.
• 48:40
  SPEAKER_00: Right.
• 48:40
  SPEAKER_00: So it's um because it's if you think about it, like lots of times something obvious would have happened, but somebody gets away on a technicality, and you will think that's not justice, this guy should have gone to jail, whatever.
• 48:52
  SPEAKER_00: Similarly, in medicine, you know, medicine as a sets of drugs and things to treat things, it's like the ambulance at the bottom of a cliff.
• 49:01
  SPEAKER_00: But to have health, you have to take personal responsibility.
• 49:05
  SPEAKER_00: So my message here is, you know, other than the fact that one is, you know, you can't have bad health and good skin.
• 49:11
  SPEAKER_00: And the second one is, you know, that's the philosophy behind the products and the ingredients which go into it.
• 49:17
  SPEAKER_00: So you can be confident that you can use it anytime and be safe.
• 49:21
  SPEAKER_00: But thirdly, um, it's the most important thing in all this is personal responsibility.
• 49:27
  SPEAKER_00: So if you don't take responsibility for your own health, then none of the other things, including the genes and proteins and other things in your body, they don't actually care.
• 49:37
  SPEAKER_00: You eat bad stuff, they're going to give you bad stuff, right?
• 49:40
  SPEAKER_00: So you will face the consequences.
• 49:42
  SPEAKER_00: So ultimately, we have to take action and be a bit proactive.
• 49:46
  SPEAKER_03: Absolutely.
• 49:47
  SPEAKER_03: I think that's, you know, very well said.
• 49:49
  SPEAKER_03: And I completely agree with you, you know, especially now, you know, as a scientist, I've tried to explain this to people and they look at me like I'm crazy.
• 49:57
  SPEAKER_03: But I'm like, you know, we live in a world where we know what epigenetics is, you know.
• 50:00
  SPEAKER_03: And for everyone listening, you know, epigenetics is basically like the modification of your genes based on the environment of your body, you know, your internal milieu.
• 50:09
  SPEAKER_03: And it's caused by so many things, like Dr.
• 50:10
  SPEAKER_03: Shradd has said here, the way you live, the way you eat, the way you sleep, you know, all of these things contribute to epigenetic changes and modifications.
• 50:19
  SPEAKER_03: And so knowing that as scientists and knowing that as um, you know, anyone really, yeah, even as a consumer, we should be approaching our health in this like holistic fashion where we're looking at everything.
• 50:32
  SPEAKER_03: You know, what am I eating?
• 50:33
  SPEAKER_03: Where am how long am I sleeping?
• 50:35
  SPEAKER_03: You know, all these things.
• 50:36
  SPEAKER_03: So I think uh, you know, that's that's definitely a message that I I think definitely resonates with me also, what you said.
• 50:44
  SPEAKER_03: Um, so I want to just talk a little bit more about the docuseries that you're um actually uh you know about to come out with.
• 50:51
  SPEAKER_03: Uh if you can share more with us, uh do we know where it's gonna be aired or haven't decided yet?
• 50:57
  SPEAKER_00: Um it was it's planned both as a theatrical kind of release as well as a streaming.
• 51:03
  SPEAKER_00: Um uh at the moment I'm not um supposed to say where it's gonna be air, so I won't say that.
• 51:10
  SPEAKER_00: But fundamentally it covers a lot of things we discussed, including things like which we don't think about.
• 51:16
  SPEAKER_00: So so for example, is with climate change and um for example, what's happening to us can so if you take a step back and you looked at say the US and what happened in in the 1970s, there was this massive um rise in uh skin cancer.
• 51:38
  SPEAKER_00: And then um after the um CFCs were banned in the aerosols um and the ozone hole started getting smaller, um, we can actually see that it plateaued.
• 51:51
  SPEAKER_00: So that was the first time we could actually see that something we did to the environment actually helped skin health.
• 51:57
  SPEAKER_00: But what I can see now is having the largest series of skin cancer patients anywhere that we can actually see the incidence rising.
• 52:06
  SPEAKER_00: And there are plenty of models which show that as our climate gets warmer everywhere, what we find is that increase in incidence of skin cancers, also things like diseases which were parasitic on skin, which we didn't think um would be in certain areas.
• 52:24
  SPEAKER_00: So if you think about Lyme disease or even Zika or things like that, one of the reasons it's a lot more widespread and not just confined to like in the case of Zika to Uganda or in the case of Lyme to certain states in the US is simply because the climate has changed.
• 52:38
  SPEAKER_00: So these things can live in many um different parts.
• 52:42
  SPEAKER_00: And and I guess that takes us back as biological beings.
• 52:45
  SPEAKER_00: And one of the other things which fascinated me, this evolutionary biology part of it, is see, we all have mites and see if you think about a human body, we're about 43% exclusively human genes, right?
• 52:59
  SPEAKER_00: Everything else we share is share with other animals and plants and viruses, bacteria, and all that kind of stuff.
• 53:05
  SPEAKER_00: So, in other words, we're only 43% exclusively human.
• 53:09
  SPEAKER_00: So, what I found really fascinating is if you look at these mites, which, as you know, uh which cause acne and various things on skin, these mites not only live in us, but they're actually they are us, they're actually part of us.
• 53:22
  SPEAKER_00: And this is the freaky part of it.
• 53:24
  SPEAKER_00: So, so we studied people, and how would you can prove that people came out of Africa is also if or human beings is doesn't matter if somebody's lived in America for generations or uh centuries.
• 53:37
  SPEAKER_00: So, what happens is if you look at African people and you did the DNA analysis of the mites, African Americans, for example, they had the mites for Africa.
• 53:47
  SPEAKER_00: And if you take it Europeans, even if they have white light skin living in Europe, they had the mites for Africa and Europe.
• 53:55
  SPEAKER_00: And if you take it Asians, they had the mites for Africa, Europe, and Asia.
• 53:59
  SPEAKER_00: So how crazy is that?
• 54:00
  SPEAKER_00: So those are the kind of things, in addition to things with diet and beauty stuff and everything else we'll cover.
• 54:06
  SPEAKER_00: But it's it's the thing about you know climate, evolution, biology, all the things you don't think about.
• 54:11
  SPEAKER_00: But this might thing really fascinated me because literally, right?
• 54:15
  SPEAKER_00: So you can tell where people came from by looking at the mites which live in their skin.
• 54:20
  SPEAKER_00: And these are the same mites which come up to the surface when you have a breakout, be it because of you know rosacea or acne or something like that.
• 54:27
  SPEAKER_00: So, anyway, that's uh there are many other things, yeah, but but in you know, that's a kind of gist is it's a big picture kind of thing of looks at everything about and why skin being our only universal organ we share with all creatures, how it actually shapes our humanity.
• 54:46
  SPEAKER_00: Obviously, we cover topics like you know, the myths of race and how human beings are all the same, but we are so divided and we can't see the entire weight of melon in our bodies is so tiny, it's 1.4 grams or something like that.
• 54:59
  SPEAKER_00: So it's like nothing, but it divides us so much, right?
• 55:03
  SPEAKER_00: Yeah, yeah.
• 55:05
  SPEAKER_03: We've had uh so many wars because of one point you say 1.5 grams.
• 55:11
  SPEAKER_00: Yes, 1.4 grams, that's right.
• 55:13
  SPEAKER_00: So so there's a lot of stuff like that.
• 55:15
  SPEAKER_00: Um, but it it's also how did we all end up like what we are?
• 55:20
  SPEAKER_00: Because it's purely the story of diet and migration.
• 55:23
  SPEAKER_00: I mean, if you listen to my talk on it, you'd see, I mean, it's just purely people migrated, ate different foods, and then it fundamentally was a battle between the folic acid in your system and the vitamin D, and all our skin colors became what they were.
• 55:38
  SPEAKER_00: So you can predict things like track and field metals at Olympics, you can take various things just looking at this evolutionary biology aspect of skin, and it's fascinating.
• 55:48
  SPEAKER_03: That's really cool.
• 55:49
  SPEAKER_03: That's really cool.
• 55:50
  SPEAKER_03: And yeah, I'm I'm glad you mentioned the TED talk because it's really, really good.
• 55:53
  SPEAKER_03: And everyone listening, I'm definitely going to be linking that as well, and as well as a lot of the books that Dr.
• 55:59
  SPEAKER_03: Straud has brought up here.
• 56:00
  SPEAKER_03: I mean, you know, I this is just it's amazing stuff what you're doing, Dr.
• 56:04
  SPEAKER_03: Straud.
• 56:05
  SPEAKER_03: I'm just so honored to have this conversation with you and and to be able to learn from you.
• 56:09
  SPEAKER_03: I mean, I think this is definitely the new frontier for, you know, skin health, what you're doing.
• 56:14
  SPEAKER_03: And I just, you know, I can't wait to see what you come up with next.
• 56:17
  SPEAKER_03: Um, for everyone listening, there are two products currently in the line that we talked about here.
• 56:22
  SPEAKER_03: One of them is the neck and face smoothing elixir, and the other one is the eye smoothing elixir.
• 56:27
  SPEAKER_03: And so I would really urge you guys, you know, get go check the both products out and really give it a go.
• 56:34
  SPEAKER_03: This is cutting edge science, you guys, like breakthrough stuff.
• 56:37
  SPEAKER_03: So, you know, Dr.
• 56:38
  SPEAKER_03: Sharon, thank you so much for coming onto the show and educating us.
• 56:42
  SPEAKER_03: Um, I would love to have you back anytime that you have the time for it.
• 56:46
  SPEAKER_00: Oh, absolutely.
• 56:47
  SPEAKER_00: I really enjoyed it.
• 56:48
  SPEAKER_00: Thank you so much.
• 56:48
  SPEAKER_00: And you know, you have such a in medical science kind of a background as well.
• 56:53
  SPEAKER_00: So, in fact, I think you did some of the explanations better than I did.
• 56:57
  SPEAKER_00: So thank you.
• 56:58
  SPEAKER_03: No, no, thank you so much.
• 57:00
  SPEAKER_03: And uh everyone listening, please make sure you give us a rating.
• 57:03
  SPEAKER_03: If you have any comments, questions for Dr.
• 57:05
  SPEAKER_03: Shroud's team, definitely leave them in the comments section for the concept art and we will pass them along.
• 57:11
  SPEAKER_03: But yeah, um, I will be back next time.
• 57:14
  SPEAKER_03: Thank you so much.
• 57:15
  SPEAKER_03: Thank you.
• 57:16
  SPEAKER_03: Hey guys, so I hope you love that episode.
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• 58:23
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