Tenecteplase in acute central retinal artery occlusion, a phase 3 Clinical Trial

Weekly Neurology Deep Dive - A review of recent impactful publications in the field of Neurology · Feb 4, 2026 · 11m

This phase 3 clinical trial, known as TenCRAOS, investigated whether the drug tenecteplase could improve vision for patients suffering from acute central retinal artery occlusion. Researchers compared the efficacy and safety of a single intravenous injection of the thrombolytic agent against a standard dose of oral aspirin when administered within a tight 4.5-hour window. The study found that tenecteplase did not provide superior vision recovery compared to aspirin, with approximately one-fifth of patients in both groups achieving the primary visual milestone. Furthermore, the experimental…