423-CyCLoPs: Monitoring In Vivo Cytokine Activity
This research introduces CyCLoPs, an innovative biological sensor designed to visualize and identify cells that respond to cytokines in living organisms. By converting the physical binding of a cytokine to its receptor into a fluorescent signal, the platform allows scientists to track immune activity with high spatial and temporal precision. The study demonstrates the tool's effectiveness by mapping IL-17A responses in the gut following bacterial colonization and identifying IFN-γ signals in tumor-infiltrating T cells. These findings reveal that cells exposed to high levels of interferon…
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