371-TNBC Response Trajectories
This article explores how triple-negative breast cancer (TNBC) responds to a combination of pembrolizumab and radiation therapy through advanced single-cell and spatial profiling. By analyzing patient biopsies over time, the authors identified 12 distinct spatial districts and three specific response trajectories among patients. While some individuals showed an immediate immune response, a second group only achieved a significant clinical benefit after the addition of radiation. Conversely, non-responders remained immunologically inactive throughout the treatment, often characterized by low…
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