1365-Sprox-seq: Multi-modal Spatial Profiling

Paper Talk · Jul 31, 2026 · 20m

The paper introduces Sprox-seq, a pioneering spatial multi-omic platform designed to simultaneously map mRNAs, protein abundance, and protein-protein interactions within intact tissue sections. By integrating proximity ligation assays with spatial transcriptomics, the technology allows researchers to visualize how molecular signaling and physical cell-cell contacts are organized geographically. When applied to human tonsil tissues, the method successfully identified distinct interaction networks in the germinal center, revealing that the light zone possesses higher complexity than the dark…