1458-NAT10-Mediated ac4C Acetylation Drives Renal Senescence
Recent research identifies NAT10 as a major driver of renal tubular epithelial cell senescence in patients suffering from diabetic nephropathy (DN). The studies demonstrate that high levels of this enzyme lead to increased ac4C acetylation, which stabilizes PAPP-A mRNA and triggers aging pathways involving the p53 protein. Experimental evidence from both type 1 and type 2 diabetes mouse models shows that inhibiting NAT10—either through genetic knockout or the pharmacological agent Remodelin—effectively reduces kidney damage and cellular aging. These findings highlight the NAT10/PAPP-A/p53…
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