1435-GABAergic Inhibitory Dysfunction in Spinal Muscular

Paper Talk · Aug 14, 2026 · 21m

This research article investigates how Survival Motor Neuron (SMN) protein deficiency causes structural and functional impairments in the motor cortex of Spinal Muscular Atrophy (SMA) mouse models. The authors demonstrate that a lack of SMN disrupts the excitatory-inhibitory balance by significantly reducing the density, morphology, and signaling of GABAergic parvalbumin-positive interneurons. This dysfunction is linked to metabolic failures in the neuron-astrocyte glutamate-glutamine cycle, specifically involving the downregulation of the SNAT5 transporter and synthesis enzymes…