240-TLS Determine Glioma Immune Microenvironment
This article details a comprehensive spatial immune profiling study focusing on adult-type diffuse gliomas, which are often considered immunologically "cold" tumors. Researchers identified tertiary lymphoid structures (TLSs) in 15% of these gliomas and further characterized them into three distinct subtypes: T-low-TLS, B:T-TLS, and PC-TLS (plasma cell rich). The study demonstrates that functional TLS maturation in gliomas, particularly the B:T-TLS and PC-TLS subtypes, involves clonal lymphocyte expansion, plasma cell formation, and interactions between cytotoxic T cells and dendritic cells…
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