1453-CFTR Potentiates Immune Microenvironment Reprogramming
This research explores the role of the CFTR chloride channel in regulating the growth and spread of hepatocellular carcinoma (HCC). Investigators discovered that CFTR expression is significantly reduced in liver cancer tissues, which correlates with more aggressive disease and poorer patient outcomes. By restoring CFTR function, researchers were able to lower intracellular levels of chloride and calcium, thereby suppressing the RUNX1 and NF-κB signaling pathways. This biochemical shift reprograms the tumor immune microenvironment by encouraging the infiltration of tumor-killing CD8+ T cells…
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