748-Pandemic-Scale Phylogenetics: Modeling Mutation Rates

Paper Talk · Apr 5, 2026 · 23m

This paper introduces advanced phylogenetic algorithms designed to process pathogen genomic data at a massive scale, specifically focusing on the evolution of SARS-CoV-2. The authors address the challenges of computational demand and data inaccuracies by implementing new models within the MAPLE software to identify mutation rate variations and recurrent sequencing errors. By distinguishing between real evolutionary changes and technical artifacts, the framework improves the accuracy of tree reconstruction for datasets containing millions of sequences. The research culminates in the creation…