1603-YBX1 Regulation of Lung Cancer Bone Metastasis
The research article identifies the transcription factor YBX1 as a central driver of bone metastasis and immunotherapy resistance in non-small cell lung cancer. By utilizing liquid-liquid phase separation, YBX1 activates specific signaling pathways that promote bone destruction and create an immunosuppressive environment rich in regulatory T cells. The study highlights that YBX1 activity is normally restricted by O-GlcNAc glycosylation, a modification that triggers its degradation through mitophagy. Researchers identified Icaritin (ICA) as a potential drug candidate that reinstates this…
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