1624-Sustained Mammalian Influenza Transmission

Paper Talk · Sep 28, 2026 · 22m

This research analyzes over 115,000 influenza A virus genomes to identify genomic traits that facilitate sustained transmission among mammals. The study reveals that viral lineages capable of long-term persistence in humans, pigs, dogs, and horses consistently exhibit a reduction in genomic GC content and specific dinucleotide frequencies over time. Using this data, the authors developed a support vector machine (SVM) model that distinguishes between viruses causing sporadic infections and those with pandemic potential with over 99% accuracy. The analysis suggests that while lower GC content…