1066-Spatial Pan-Cancer Atlas of lncRNAs

Paper Talk · Jun 2, 2026 · 22m

This research introduces SPanC-Lnc, a comprehensive pan-cancer atlas designed to map long noncoding RNAs (lncRNAs) using single-cell and spatial transcriptomics. By analyzing over 219,000 potential lncRNAs across 13 different cancer types, the study identifies nearly 95,000 previously unannotated transcripts. The authors utilize advanced long-read sequencing and various spatial platforms to validate these findings and determine cell-type specificity. Beyond identification, the work explores lncRNA functions through spatial coexpression with known cancer-hallmark genes and regulatory features…