674-NF-κB Control Prostate Stem Cell Plasticity

Paper Talk · Mar 21, 2026 · 21m

This research article examines how Pten deletion triggers the transformation of adult prostate basal cells into multi-lineage stem cells, leading to the initiation of invasive tumors. Through techniques like single-cell RNA sequencing, the authors discovered that this cellular plasticity occurs primarily in specific prostate regions and is driven by the activation of innate immunity and the NF-κB signaling pathway. The study highlights that the cell of origin significantly dictates how aggressive a tumor becomes, noting that cancers derived from basal cells often exhibit more inflammation and…