1272-Mapping Invasive-Front Signature of Bladder Cancer
This article details a spatial transcriptomic study of non-muscle-invasive bladder cancer using high-quality en bloc resection specimens. By preserving the three-dimensional architecture of the tissue, researchers identified a distinct 15-gene signature specifically enriched at the tumor-boundary region, or invasive front. These genes are primarily associated with epithelial-mesenchymal transition and extracellular matrix remodeling, processes that facilitate cancer cell migration and invasion. Analysis of public datasets further suggests that high expression of this signature correlates with…
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