1545-Virome-Wide Discovery of Diverse Viral UbiquitinLigases
This research article describes a high-throughput pooled genetic screen designed to identify viral proteins, termed "degradins," that manipulate the host’s ubiquitin-proteasome system to facilitate infection. By testing a library of approximately 10,000 viral open reading frames, the study discovered various mechanisms that viruses use to bypass or hijack host immune responses. The authors categorized these viral ubiquitin ligases into canonical, noncanonical, and hijacker classes based on how they interface with host Cullin-RING ligases. Detailed structural and proteomic analyses revealed…
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