1681-Cargo Crosslinking and AP-1 Lattice Formation
Recent scientific research reveals that intracellular transport vesicles are actively shaped by their contents rather than relying solely on coat-driven mechanisms. By employing cryogenic-electron microscopy, investigators discovered that specific proteins containing tandem sorting motifs can directly bridge adjacent AP-1 adaptor complexes to nucleate lattice assembly. This crosslinking occurs through a newly identified μ1-σ1 inter-complex interface that transforms weak individual interactions into a stable architectural framework. Cellular assays and animal models further demonstrate that…
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