1605-Spatiotemporal Organisation in Breast Cancer
The research paper details a comprehensive study of minimal residual disease (MRD) in BRCA1-deficient breast cancers using multiomic spatial profiling in both mouse models and human patients. By integrating single-cell RNA sequencing, spatial transcriptomics, and imaging mass cytometry, the researchers identified a specific chemotherapy-tolerant niche characterized by epithelial-mesenchymal transition (EMT) and cellular quiescence. This distinct population of cancer cells survives treatment without acquiring permanent genetic mutations, instead relying on phenotypic plasticity to persist and…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.