1195-Spatial Pharmacobiology of Antibody Delivery
The paper introduces Single-Cell Spatial Pharmacobiology (SSP), a novel analytical framework designed to visualize and measure how therapeutic antibodies interact with human solid tumors. By combining fluorescently labeled drug imaging with multiplexed spatial proteomics, researchers can now observe drug distribution and target engagement at cellular resolution rather than relying on low-resolution systemic scans. Investigations into patients with head and neck and pancreatic cancers revealed that drug delivery is significantly hindered by specific tumor microenvironment (TME) structures…
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