904-Prefrontal TMS Therapy for Depression

Paper Talk · May 5, 2026 · 22m

This research investigates the neuroanatomical pathways that facilitate transcranial magnetic stimulation (TMS) for treating depression. Using connectome modeling, the authors demonstrate that the therapy’s success depends on polysynaptic fiber routes connecting the dorsolateral prefrontal cortex to the subgenual cingulate. Their findings reveal that patients experience better clinical outcomes when their specific stimulation sites have shorter, more direct white matter paths to target regions. The study identifies three primary cortical and subcortical circuits, including fronto-thalamic…