1157-ISG Atlas: Functional Map of Antiviral Innate Immunity

Paper Talk · Jun 20, 2026 · 24m

This research introduces The ISG Atlas, a comprehensive resource detailing how hundreds of interferon-stimulated genes (ISGs) modulate viral infections. By utilizing a time-resolved loss-of-function screen, the authors systematically analyzed the effects of 285 ISGs against a diverse panel of eight different viruses. The study identifies both pan-antiviral factors that work against many pathogens and virus-specific genes with more narrow targets. A key discovery highlights the protein BORCS8, which restricts SARS-CoV-2 by promoting the acidification of endosomes to degrade viral particles…