1179-KRAS Phase Separation in Colon Cancer
Research identifies a critical regulatory mechanism in which KRAS proteins form cytoplasmic condensates through a process called liquid-liquid phase separation (LLPS). This phenomenon is specifically driven by farnesylation, a hydrophobic modification at the C185 residue that enables KRAS to aggregate into membrane-less droplets. These condensates facilitate essential protein processing by clustering with enzymes at the endoplasmic reticulum, which ultimately promotes tumor growth and correlates with advanced stages of colon cancer. While growth factors stimulate the formation of these…
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