Why SIBO Comes Back After Rifaximin (3 Reasons Symptoms Return After Antibiotics)

The Gut Health Dialogues · Mar 31, 2026 · 31m

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If you’ve taken antibiotics like rifaximin for SIBO and found yourself right back where you started, you’re not alone. This is one of the most common patterns we see in practice, and it’s also one of the most frustrating.

In this episode, Alyssa breaks down what’s actually happening beneath the surface when symptoms return, and why repeating the same approach often leads to the same outcome. You’ll learn how different SIBO patterns behave, why treatment sometimes only scratches the surface, and what’s often missing from conventional care that leads to relapse.

We’ll cover…