Latest / APS Publications Podcast
Interorgan Insights: Beyond the pancreas-amylin's role in diabetes pathogenesis
In this podcast, coauthors Alice E. Knapton and Andrew Murray discuss their recently published article, ‘Amyloid-Forming Amylin Secreted by the Pancreas Promotes Hypoxia-Inducible Factor Activation and Mitochondrial Alterations in Liver and Heart During Type 2 Diabetes Pathogenesis’. The article describes a collaborative study examining how amyloid-forming human amylin, a hormone that is hypersecreted in insulin resistance and type 2 diabetes, may affect organs beyond the pancreas. Using the HIP rat model, the researchers investigated links between amylin aggregation, hypoxia-inducible factor…
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