1217-Irg1/Itaconate Rewires Macrophage and Tumor Metabolism
This research identifies IRG1-derived itaconate as a critical metabolic regulator that restricts lung cancer progression. By employing spatial metabolomics, the authors discovered that itaconate is naturally depleted within tumor regions, and its absence accelerates malignant growth and metastasis. Mechanistically, itaconate inhibits G6PD activity, which suppresses the pentose phosphate pathway and reduces the production of essential building blocks for cancer cell proliferation. Furthermore, restoring itaconate levels through the derivative Octyl itaconate successfully reprograms pro-tumor…
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