289-The TIG1 Primes Cells for SARS-CoV-2 Infection

Paper Talk · Dec 3, 2025 · 14m

The article details research on why individual cells exhibit variable susceptibility to viral infection, even within a homogeneous cell type. The authors used a retrospective single-cell technique called Rewind to identify specific intrinsic cell states, such as the TIG1-high state, that make cells highly susceptible to SARS-CoV-2 and, separately, a distinct state susceptible to influenza A virus. This research establishes that a cell's transcriptional state prior to infection is a major determinant of whether it will be infected, showing that ACE2 expression alone is insufficient to predict…