013-Glioblastoma Ecosystems

Paper Talk · Aug 2, 2025 · 1h 2m

Glioblastoma Ecosystems: Transcriptional Architecture and Cellular States

This article investigates the multilayered transcriptional architecture of glioblastoma (GBM) ecosystems, focusing on tumor heterogeneity, which is a key driver of therapeutic resistance in this aggressive brain cancer. The authors utilized single-nucleus RNA sequencing and bulk DNA sequencing on a large cohort of GBM samples to identify distinct malignant cellular states, including novel ones, and to characterize intertumor heterogeneity through baseline gene expression programs. The research further explores the…