1344-Non-Genotoxic Epitope Editing

Paper Talk · Jul 27, 2026 · 23m

Researchers have developed a non-genotoxic method for haematopoietic stem cell transplantation that replaces traditional chemotherapy and radiation with targeted immunotherapy. By using adenine base editing, the team introduced specific epitope mutations into the KIT receptor of donor cells, rendering them resistant to monoclonal antibodies while maintaining normal cellular function. This technique allows for the in vivo selection of engineered cells, as clinicians can administer antibodies to deplete diseased host cells without harming the transplanted, edited ones. The study successfully…