663-Predictors of Response to Immune therapy in TNBC
The paper describes a study published in Nature Cancer that utilized multiplexed ion beam imaging (MIBI) and longitudinal profiling to identify biomarkers for immunotherapy response in metastatic triple-negative breast cancer. By analyzing 103 patients from the TONIC trial, researchers developed SpaceCat, an open-source pipeline that extracts over 800 spatial features from the tumor microenvironment. The study found that on-treatment metastatic biopsies were significantly more predictive of patient outcomes than primary tumors or baseline samples. High-performing multivariate models revealed…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.