218-Benchmarking Functional Connectivity Mapping Methods

Paper Talk · Nov 9, 2025 · 22m

This paper benchmarks the various methods used to map functional connectivity (FC) in the brain using functional magnetic resonance imaging (fMRI). Researchers systematically compared a large library of 239 pairwise interaction statistics to assess how the choice of statistic impacts key features of FC networks, such as hub mapping, structure-function coupling, and brain-behavior prediction. The study found substantial quantitative and qualitative variation across these methods, noting that measures like precision and covariance often display desirable properties, including better alignment…