1223-Host Immune Dynamics After CAR T Therapy in GBM
This article examines the immune system's reaction to a specific cancer treatment known as intracerebroventricular CAR T cell therapy in patients with recurrent glioblastoma. Researchers utilized advanced single-cell RNA sequencing and spectral cytometry to observe how both the engineered cells and the patient's own endogenous immune compartment change after infusion. The study highlights that the presence of host immune cells in the cerebrospinal fluid significantly evolves following treatment, potentially influencing the therapy's overall success. Data collected from various patient cohorts…
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