1381-Patient-derived Organoids Reveal Ductal Dysfunction
This research article examines the use of patient-derived organoids (PDOs) to study the cellular mechanics of chronic pancreatitis (CP). By establishing a biobank of 37 organoid models, researchers identified three molecular subtypes of the disease that exist regardless of the original cause of inflammation. The study highlights how these models retain the intrinsic inflammatory traits found in human patients, specifically focusing on ductal dysfunction. A significant finding involves the use of CFTR modulators to repair impaired transport pathways in organoids with genetic mutations…
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