971-Somatic Cancer Variants in Alzheimer’s Disease Microglia
This research demonstrates that Alzheimer's disease (AD) is linked to an increased presence of somatic cancer driver variants within the brain's immune landscape. Specifically, these genetic mutations are enriched in microglia-like brain macrophages (MLBMs), driving them toward harmful pro-inflammatory and proliferative states that mirror disease-associated signatures. Evidence suggests these mutant cells may originate from blood-derived monocytes that infiltrate the brain due to age-related barrier degradation. By utilizing single-cell multi-omic analyses and iPSC-derived models, the authors…
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