1630-Spatial Niche Dysregulation in Pulmonary Fibrosis

Paper Talk · Sep 30, 2026 · 22m

This research utilizes advanced spatial transcriptomics to map the cellular and molecular landscape of pulmonary fibrosis across 1.6 million individual cells. By analyzing lung tissue with subcellular precision, the authors identified 47 distinct cell types and discovered specific spatial niches where disease-driving interactions occur. A key finding is that even architecturally normal areas in diseased lungs exhibit significant molecular dysregulation, suggesting that cellular changes precede visible structural damage. The study also highlights the role of aberrant basaloid cells in…