980-Architecting Human Trunk Development
Researchers have successfully engineered human trunk-like structures (hTLS) using pluripotent stem cells to investigate the complex co-development of the neural tube and somites. By precisely adjusting chemical signaling during the growth process, the team created 3D models that replicate the morphological organization and gene expression of a human embryo at approximately four to five weeks of development. These synthetic models allow scientists to observe how different tissues interact and influence each other's growth, such as how retinoic acid from somites helps pattern the nervous…
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