853-Architectural Secrets of the Mouse Cytoplasmic Lattice

Paper Talk · Apr 25, 2026 · 24m

This research paper describes the atomistic-resolution structure of the mouse cytoplasmic lattice (CPL), a massive protein storage organelle essential for mammalian reproduction. Using single-particle cryo-electron microscopy, scientists determined that the CPL is a 4-MDa repeating unit featuring a tripartite architecture of an external framework, linkers, and a core. The study reveals how this lattice sequesters and inhibits vital maternal factors, such as the epigenetic regulator UHRF1, GTP-bound tubulin, and ubiquitin ligase components. These stored proteins are held in a poised but…